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The Testosterone-Derived Neurosteroid Androstanediol Is a Positive Allosteric Modulator of GABA(A) Receptors
Testosterone modulates seizure susceptibility, but the underlying mechanisms are obscure. Recently, we demonstrated that testosterone affects seizure activity via its conversion to neurosteroids in the brain. Androstanediol (5α-androstan-3α,17β-diol) is an endogenous neurosteroid synthesized from te...
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| Auteurs principaux: | , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
The American Society for Pharmacology and Experimental Therapeutics
2010
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939675/ https://ncbi.nlm.nih.gov/pubmed/20551294 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.169854 |
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