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Altered Protein Kinase C Regulation of Pulmonary Endothelial Store- and Receptor-Operated Ca(2+) Entry after Chronic Hypoxia

Chronic hypoxia (CH)-induced pulmonary hypertension is associated with decreased basal pulmonary artery endothelial cell (EC) Ca(2+), which correlates with reduced store-operated Ca(2+) (SOC) entry. Protein kinase C (PKC) attenuates SOC entry in ECs. Therefore, we hypothesized that PKC has a greater...

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書誌詳細
主要な著者: Paffett, Michael L., Riddle, Melissa A., Kanagy, Nancy L., Resta, Thomas C., Walker, Benjimen R.
フォーマット: Artigo
言語:Inglês
出版事項: The American Society for Pharmacology and Experimental Therapeutics 2010
主題:
オンライン・アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939669/
https://ncbi.nlm.nih.gov/pubmed/20576798
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.165563
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