Pretreatment of Guinea Pigs with Galantamine Prevents Immediate and Delayed Effects of Soman on Inhibitory Synaptic Transmission in the Hippocampus

Galantamine has emerged as a potential antidote to prevent the acute toxicity of organophosphorus (OP) compounds. Changes in inhibitory GABAergic activity in different brain regions can contribute to both induction and maintenance of seizures in subjects exposed to the OP nerve agent soman. Here, we...

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Autors principals: Alexandrova, Elena A., Aracava, Yasco, Pereira, Edna F. R., Albuquerque, Edson X.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Pharmacology and Experimental Therapeutics 2010
Matèries:
Toxicology
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939667/
https://ncbi.nlm.nih.gov/pubmed/20554906
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.110.167700
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