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Non-stereo-selective cytosolic human brain tissue 3-ketosteroid reductase is refractory to inhibition by AKR1C inhibitors

Cerebral 3α-hydroxysteroid dehydrogenase (3α-HSD) activity was suggested to be responsible for the local directed formation of neuroactive 5α,3α-tetrahydrosteroids (5α,3α-THSs) from 5α-dihydrosteroids. We show for the first time that within human brain tissue 5α-dihydroprogesterone and 5α-dihydrotes...

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Detalhes bibliográficos
Main Authors: Steckelbroeck, Stephan, Lütjohann, Dieter, Bauman, David R., Ludwig, Michael, Friedl, Anke, Hans, Volkmar H.J., Penning, Trevor M., Klingmüller, Dietrich
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939277/
https://ncbi.nlm.nih.gov/pubmed/20673851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2010.07.005
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