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NEUROSTEROID WITHDRAWAL REGULATES GABA-A RECEPTOR α4-SUBUNIT EXPRESSION AND SEIZURE SUSCEPTIBILITY BY ACTIVATION OF PR-INDEPENDENT EGR3 PATHWAY
Neurosteroids regulate GABA-A receptor plasticity. Neurosteroid withdrawal occurs during menstruation and is associated with a marked increase in expression of GABA-A receptor α4-subunit, a key subunit linked to enhanced neuronal excitability, seizure susceptibility and benzodiazepine resistance. Ho...
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| Main Authors: | , |
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| Format: | Artigo |
| Jezik: | Inglês |
| Izdano: |
2010
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| Teme: | |
| Online dostop: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2939139/ https://ncbi.nlm.nih.gov/pubmed/20670676 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.neuroscience.2010.07.037 |
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