Hybrid Molecular Structure of the Giant Protease Tripeptidyl Peptidase II

Tripeptidyl peptidase II (TPP II) is the largest known eukaryotic protease (6MDa). It is believed to act downstream of the 26S proteasome cleaving tripeptides from the N– termini of longer peptides and it is implicated in numerous cellular processes. Here we report the structure of Drosophila TPP II...

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Bibliographic Details
Main Authors: Chuang, Crystal K., Rockel, Beate, Seyit, Gönül, Walian, Peter J., Schönegge, Anne–Marie, Peters, Jürgen, Zwart, Petrus H., Baumeister, Wolfgang, Jap, Bing K.
Format: Artigo
Language:Inglês
Published: 2010
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2939011/
https://ncbi.nlm.nih.gov/pubmed/20676100
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nsmb.1870
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