Comparisons between Chemical Mapping and Binding to Isoenergetic Oligonucleotide Microarrays Reveal Unexpected Patterns of Binding to the Bacillus subtilis RNase P RNA Specificity Domain

[Image: see text] Microarrays with isoenergetic pentamer and hexamer 2′-O-methyl oligonucleotide probes with LNA (locked nucleic acid) and 2,6-diaminopurine substitutions were used to probe the binding sites on the RNase P RNA specificity domain of Bacillus subtilis. Unexpected binding patterns were...

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Bibliographic Details
Main Authors: Liang, Ruiting, Kierzek, Elzbieta, Kierzek, Ryszard, Turner, Douglas H.
Format: Artigo
Language:Inglês
Published: American Chemical Society 2010
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938832/
https://ncbi.nlm.nih.gov/pubmed/20557101
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/bi100286n
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