Endothelin (ET)-3 stimulates cyclic guanosine 3',5'-monophosphate production via ETB receptor by producing nitric oxide in isolated rat glomerulus, and in cultured rat mesangial cells.

We investigated the effects of endothelins on receptor-mediated cyclic nucleotide metabolism in rat glomerulus, inner medullary collecting duct (IMCD), and also in cultured rat glomerular mesangial cells. Endothelin (ET)-3 dose-dependently stimulated cGMP accumulation in glomerulus, which was higher...

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Pubblicato in:	J Clin Invest
Autori principali:	Owada, A, Tomita, K, Terada, Y, Sakamoto, H, Nonoguchi, H, Marumo, F
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	American Society for Clinical Investigation 1994
Soggetti:	Research Article
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293878/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/7509343/ https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI117007
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