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Hypoxia-inducible Factor-1 Activation in Nonhypoxic Conditions: The Essential Role of Mitochondrial-derived Reactive Oxygen Species

Hypoxia-inducible factor-1 (HIF-1) is a key transcription factor for responses to low oxygen. Different nonhypoxic stimuli, including hormones and growth factors, are also important HIF-1 activators in the vasculature. Angiotensin II (Ang II), the main effecter hormone in the renin-angiotensin syste...

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Autors principals: Patten, David A., Lafleur, Véronique N., Robitaille, Geneviève A., Chan, Denise A., Giaccia, Amato J., Richard, Darren E.
Format: Artigo
Idioma:Inglês
Publicat: The American Society for Cell Biology 2010
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938389/
https://ncbi.nlm.nih.gov/pubmed/20660157
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1091/mbc.E10-01-0025
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