Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis

BACKGROUND: Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe membranoproliferative lupus nephritis in (NZBxNZW)F1 mice...

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Hlavní autoři: Zykova, Svetlana N., Tveita, Anders A., Rekvig, Ole Petter
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938370/
https://ncbi.nlm.nih.gov/pubmed/20856893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012096
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