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Renal Dnase1 Enzyme Activity and Protein Expression Is Selectively Shut Down in Murine and Human Membranoproliferative Lupus Nephritis

BACKGROUND: Deposition of chromatin-IgG complexes within glomerular membranes is a key event in the pathogenesis of lupus nephritis. We recently reported an acquired loss of renal Dnase1 expression linked to transformation from mild to severe membranoproliferative lupus nephritis in (NZBxNZW)F1 mice...

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Bibliografiske detaljer
Main Authors: Zykova, Svetlana N., Tveita, Anders A., Rekvig, Ole Petter
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938370/
https://ncbi.nlm.nih.gov/pubmed/20856893
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012096
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