Regulation of Heparin-Binding EGF-Like Growth Factor by miR-212 and Acquired Cetuximab-Resistance in Head and Neck Squamous Cell Carcinoma

BACKGROUND: We hypothesized that chronic inhibition of epidermal growth factor receptor (EGFR) by cetuximab, a monoclonal anti-EGFR antibody, induces up-regulation of its ligands resulting in resistance and that microRNAs (miRs) play an important role in the ligand regulation in head and neck squamo...

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Detalhes bibliográficos
Main Authors: Hatakeyama, Hiromitsu, Cheng, Haixia, Wirth, Pamela, Counsell, Ashley, Marcrom, Samuel R., Wood, Carey Burton, Pohlmann, Paula R., Gilbert, Jill, Murphy, Barbara, Yarbrough, Wendell G., Wheeler, Deric L., Harari, Paul M., Guo, Yan, Shyr, Yu, Slebos, Robbert J., Chung, Christine H.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2010
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938338/
https://ncbi.nlm.nih.gov/pubmed/20856931
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012702
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