Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma

BACKGROUND: Suppressive immune cells present in tumour microenvironments are known to augment tumour growth and hamper efficacy of antitumour therapies. The amino-bisphosphonate Zoledronic acid (ZA) is considered as an antitumour agent, as recent studies showed that ZA prolongs disease-free survival...

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Bibliographic Details
Main Authors:	Veltman, J D, Lambers, M E H, van Nimwegen, M, Hendriks, R W, Hoogsteden, H C, Hegmans, J P J J, Aerts, J G J V
Format:	Artigo
Language:	Inglês
Published:	Nature Publishing Group 2010
Subjects:	Translational Therapeutics
Online Access:	https://ncbi.nlm.nih.gov/pmc/articles/PMC2938257/ https://ncbi.nlm.nih.gov/pubmed/20664588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6605814
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Zoledronic acid impairs myeloid differentiation to tumour-associated macrophages in mesothelioma

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