TOR-dependent reduction in the expression level of Rrn3p lowers the activity of the yeast RNA Pol I machinery, but does not account for the strong inhibition of rRNA production

Eitemau Tebyg

• Reduction in Ribosomal Protein Synthesis Is Sufficient To Explain Major Effects on Ribosome Production after Short-Term TOR Inactivation in Saccharomyces cerevisiae
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• Site specific phosphorylation of yeast RNA polymerase I
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• RNA polymerase I (Pol I) passage through nucleosomes depends on Pol I subunits binding its lobe structure
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  Cyhoeddwyd: (2020)
• A specialized form of RNA polymerase I, essential for initiation and growth-dependent regulation of rRNA synthesis, is disrupted during transcription.
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• Two tRNA gene clusters associated with rRNA operons rrnD and rrnE in Bacillus subtilis.
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