Inhibition of cyclin D1 expression by androgen receptor in breast cancer cells—identification of a novel androgen response element

Cyclin D1 gene (CCND1) is a critical mitogen-regulated cell-cycle control element whose transcriptional modulation plays a crucial role in breast cancer growth and progression. Here we demonstrate that the non-aromatizable androgen 5-α-dihydrotestosterone (DHT) inhibits endogenous cyclin D1 expressi...

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Détails bibliographiques
Auteurs principaux: Lanzino, Marilena, Sisci, Diego, Morelli, Catia, Garofalo, Cecilia, Catalano, Stefania, Casaburi, Ivan, Capparelli, Claudia, Giordano, Cinzia, Giordano, Francesca, Maggiolini, Marcello, Andò, Sebastiano
Format: Artigo
Langue:Inglês
Publié: Oxford University Press 2010
Sujets:
Gene Regulation, Chromatin and Epigenetics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2938215/
https://ncbi.nlm.nih.gov/pubmed/20421209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/nar/gkq278
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