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High-throughput immunoglobulin repertoire analysis distinguishes between human IgM memory and switched memory B-cell populations
B-cell receptor (BCR) diversity is achieved centrally by rearrangement of Variable, Diversity, and Joining genes, and peripherally by somatic hypermutation and class-switching of the rearranged genes. Peripheral B-cell populations are subject to both negative and positive selection events in the cou...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Society of Hematology
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2938129/ https://ncbi.nlm.nih.gov/pubmed/20457872 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1182/blood-2010-03-275859 |
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