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Interleukin-10 prevents spontaneous death of germinal center B cells by induction of the bcl-2 protein.

In this study, we show that IL-10 enhances in vitro the viability of purified splenic B cells. There was a two- to threefold increase in recovery of viable cells during a 15-d culture period in the presence of IL-10. This effect was abolished by neutralizing antibodies to IL-10. The survival of larg...

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Detalhes bibliográficos
Main Authors: Levy, Y, Brouet, J C
Formato: Artigo
Idioma:Inglês
Publicado em: 1994
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC293803/
https://ncbi.nlm.nih.gov/pubmed/8282815
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