IL-1-induced Post-transcriptional Mechanisms Target Overlapping Translational Silencing and Destabilizing Elements in IκBζ mRNA

The inflammatory cytokine IL-1 induces profound changes in gene expression. This is contributed in part by activating translation of a distinct set of mRNAs, including IκBζ, as indicated by genome-wide analysis of changes in ribosomal occupancy in IL-1α-treated HeLa cells. Polysome profiling of IκBζ...

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Bibliographic Details
Main Authors: Dhamija, Sonam, Doerrie, Anneke, Winzen, Reinhard, Dittrich-Breiholz, Oliver, Taghipour, Azadeh, Kuehne, Nancy, Kracht, Michael, Holtmann, Helmut
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
RNA
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937947/
https://ncbi.nlm.nih.gov/pubmed/20634286
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.146365
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