Alkaline Ceramidase 2 (ACER2) and Its Product Dihydrosphingosine Mediate the Cytotoxicity of N-(4-Hydroxyphenyl)retinamide in Tumor Cells

Increased generation of dihydrosphingosine (DHS), a bioactive sphingolipid, has been implicated in the cytotoxicity of the synthetic retinoid N-(4-hydroxyphenyl)retinamide (4-HPR) in tumor cells. However, how 4-HPR increases DHS remains unclear. Here we demonstrate that 4-HPR increases the expressio...

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Главные авторы: Mao, Zhehao, Sun, Wei, Xu, Ruijuan, Novgorodov, Sergei, Szulc, Zdzislaw M., Bielawski, Jacek, Obeid, Lina M., Mao, Cungui
Формат: Artigo
Язык:Inglês
Опубликовано: American Society for Biochemistry and Molecular Biology 2010
Предметы:
Lipids
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937939/
https://ncbi.nlm.nih.gov/pubmed/20628055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.105296
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