Substrate Specificity, Membrane Topology, and Activity Regulation of Human Alkaline Ceramidase 2 (ACER2)

Human alkaline ceramidase 2 (ACER2) plays an important role in cellular responses by regulating the hydrolysis of ceramides in cells. Here we report its biochemical characterization, membrane topology, and activity regulation. Recombinant ACER2 was expressed in yeast mutant cells (Δypc1Δydc1) that l...

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Main Authors: Sun, Wei, Jin, Junfei, Xu, Ruijuan, Hu, Wei, Szulc, Zdzislaw M., Bielawski, Jacek, Obeid, Lina M., Mao, Cungui
Format: Artigo
Jezik:Inglês
Izdano: American Society for Biochemistry and Molecular Biology 2010
Teme:
Lipids
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2838321/
https://ncbi.nlm.nih.gov/pubmed/20089856
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.069203
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