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The 3′ Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA

In the process of translation of eukaryotic mRNAs, the 5′ cap and the 3′ poly(A) tail interact synergistically to stimulate protein synthesis. Unlike its cellular counterparts, the small mRNA (SmRNA) of Andes hantavirus (ANDV), a member of the Bunyaviridae, lacks a 3′ poly(A) tail. Here we report th...

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Main Authors: Vera-Otarola, Jorge, Soto-Rifo, Ricardo, Ricci, Emiliano P., Ohlmann, Théophile, Darlix, Jean-Luc, López-Lastra, Marcelo
格式: Artigo
語言:Inglês
出版: American Society for Microbiology (ASM) 2010
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在線閱讀:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937818/
https://ncbi.nlm.nih.gov/pubmed/20660206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01270-10
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