The 3′ Untranslated Region of the Andes Hantavirus Small mRNA Functionally Replaces the Poly(A) Tail and Stimulates Cap-Dependent Translation Initiation from the Viral mRNA

In the process of translation of eukaryotic mRNAs, the 5′ cap and the 3′ poly(A) tail interact synergistically to stimulate protein synthesis. Unlike its cellular counterparts, the small mRNA (SmRNA) of Andes hantavirus (ANDV), a member of the Bunyaviridae, lacks a 3′ poly(A) tail. Here we report th...

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Bibliographic Details
Main Authors: Vera-Otarola, Jorge, Soto-Rifo, Ricardo, Ricci, Emiliano P., Ohlmann, Théophile, Darlix, Jean-Luc, López-Lastra, Marcelo
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937818/
https://ncbi.nlm.nih.gov/pubmed/20660206
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01270-10
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