Chromosomal Integration of Adenoviral Vector DNA In Vivo

So far there has been no report of any clinical or preclinical evidence for chromosomal vector integration following adenovirus (Ad) vector-mediated gene transfer in vivo. We used liver gene transfer with high-capacity Ad vectors in the FAH(Δexon5) mouse model to analyze homologous and heterologous...

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Main Authors: Stephen, Sam Laurel, Montini, Eugenio, Sivanandam, Vijayshankar Ganesh, Al-Dhalimy, Muhseen, Kestler, Hans A., Finegold, Milton, Grompe, Markus, Kochanek, Stefan
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
Teme:
Gene Delivery
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937808/
https://ncbi.nlm.nih.gov/pubmed/20686029
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.00751-10
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