Nucleotide Variability and Translation Efficiency of the 5′ Untranslated Region of Hepatitis A Virus: Update from Clinical Isolates Associated with Mild and Severe Hepatitis

Mutations in the internal ribosome entry site (IRES) of hepatitis A virus (HAV) have been associated with enhanced in vitro replication and viral attenuation in animal models. To address the possible role of IRES variability in clinical presentation, IRES sequences were obtained from HAV isolates as...

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Hauptverfasser: Mackiewicz, Vincent, Cammas, Anne, Desbois, Delphine, Marchadier, Eric, Pierredon, Sandra, Beaulieux, Frédérik, Dussaix, Elisabeth, Vagner, Stephan, Roque-Afonso, Anne-Marie
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2010
Schlagworte:
Genetic Diversity and Evolution
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937785/
https://ncbi.nlm.nih.gov/pubmed/20631141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02598-09
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