Nucleotide Variability and Translation Efficiency of the 5′ Untranslated Region of Hepatitis A Virus: Update from Clinical Isolates Associated with Mild and Severe Hepatitis

Mutations in the internal ribosome entry site (IRES) of hepatitis A virus (HAV) have been associated with enhanced in vitro replication and viral attenuation in animal models. To address the possible role of IRES variability in clinical presentation, IRES sequences were obtained from HAV isolates as...

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Bibliographic Details
Main Authors: Mackiewicz, Vincent, Cammas, Anne, Desbois, Delphine, Marchadier, Eric, Pierredon, Sandra, Beaulieux, Frédérik, Dussaix, Elisabeth, Vagner, Stephan, Roque-Afonso, Anne-Marie
Format: Artigo
Language:Inglês
Published: American Society for Microbiology (ASM) 2010
Subjects:
Genetic Diversity and Evolution
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937785/
https://ncbi.nlm.nih.gov/pubmed/20631141
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02598-09
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