Evolutionarily Conserved Role of Calcineurin in Phosphodegron-Dependent Degradation of Phosphodiesterase 4D

Calcineurin is a widely expressed and highly conserved Ser/Thr phosphatase. Calcineurin is inhibited by the immunosuppressant drug cyclosporine A (CsA) or tacrolimus (FK506). The critical role of CsA/FK506 as an immunosuppressant following transplantation surgery provides a strong incentive to under...

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Main Authors: Zhu, Hong, Suk, Hee Yun, Yu, Raymond Y. L., Brancho, Deborah, Olabisi, Opeyemi, Yang, Teddy T. C., Yang, XiaoYong, Zhang, Jialin, Moussaif, Mustapha, Durand, Jorge L., Jelicks, Linda A., Kim, Ja-Young, Scherer, Philipp E., Frank, Philippe G., Lisanti, Michael P., Calvert, John W., Duranski, Mark R., Lefer, David J., Huston, Elaine, Baillie, George S., Houslay, Miles D., Molkentin, Jeffrey D., Jin, Jianping, Chow, Chi-Wing
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology (ASM) 2010
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Articles
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937537/
https://ncbi.nlm.nih.gov/pubmed/20647544
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/MCB.01193-09
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