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Phosphodiesterase-4 influences the PKA phosphorylation status and membrane translocation of G-protein receptor kinase 2 (GRK2) in HEK-293β2 cells and cardiac myocytes
Membrane-recruitment of GRK2 (G-protein receptor kinase 2) provides a fundamental step in the desensitization process controlling GPCRs (G-protein-coupled receptors), such as the β(2)AR (β(2)-adrenergic receptor). In the present paper, we show that challenge of HEK-293β2 [human embryonic kidney cell...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Portland Press Ltd.
2006
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC1408673/ https://ncbi.nlm.nih.gov/pubmed/16356165 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1042/BJ20051560 |
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