Plasmodium vivax Ookinete Surface Protein Pvs25 Linked to Cholera Toxin B Subunit Induces Potent Transmission-Blocking Immunity by Intranasal as Well as Subcutaneous Immunization

The nontoxic cholera toxin B subunit (CTB) was evaluated as a potential delivery molecule for the Plasmodium vivax ookinete surface protein, Pvs25. Recombinant Pvs25 was expressed as a secreted protein in the yeast Pichia pastoris, as a mixture of isoforms including multimers and the A and B monomer...

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Detalhes bibliográficos
Main Authors: Miyata, Takeshi, Harakuni, Tetsuya, Tsuboi, Takafumi, Sattabongkot, Jetsumon, Kohama, Hideyasu, Tachibana, Mayumi, Matsuzaki, Goro, Torii, Motomi, Arakawa, Takeshi
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Microbial Immunity and Vaccines
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937454/
https://ncbi.nlm.nih.gov/pubmed/20584978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/IAI.00306-10
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