O-Fucosylation of Thrombospondin Type 1 Repeats Restricts Epithelial to Mesenchymal Transition (EMT) and Maintains Epiblast Pluripotency During Mouse Gastrulation

Thrombospondin type 1 repeat (TSR) superfamily members regulate diverse biological activities ranging from cell motility to inhibition of angiogenesis. In this study, we verified that mouse protein O-fucosyltransferase-2 (POFUT2) specifically adds O-fucose to TSRs. Using two Pofut2 gene trap lines,...

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Main Authors: Du, Jianguang, Takeuchi, Hideyuki, Leonhard-Melief, Christina, Shroyer, Kenneth R., Dlugosz, Malgosia, Haltiwanger, Robert S., Holdener, Bernadette C.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2937101/
https://ncbi.nlm.nih.gov/pubmed/20637190
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.ydbio.2010.07.008
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