O-Fucosylation of ADAMTSL2 is required for secretion and is impacted by geleophysic dysplasia-causing mutations

ADAMTSL2 mutations cause an autosomal recessive connective tissue disorder, geleophysic dysplasia 1 (GPHYSD1), which is characterized by short stature, small hands and feet, and cardiac defects. ADAMTSL2 is a matricellular protein previously shown to interact with latent transforming growth factor-β...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:J Biol Chem
Prif Awduron: Zhang, Ao, Berardinelli, Steven J., Leonhard-Melief, Christina, Vasudevan, Deepika, Liu, Ta-Wei, Taibi, Andrew, Giannone, Sharee, Apte, Suneel S., Holdener, Bernadette C., Haltiwanger, Robert S.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Society for Biochemistry and Molecular Biology 2020
Pynciau:
Glycobiology and Extracellular Matrices
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC7667967/
https://ncbi.nlm.nih.gov/pubmed/32913123
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA120.014557
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