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Cortical Regulation of Striatal Medium Spiny Neuron Dendritic Remodeling in Parkinsonism: Modulation of Glutamate Release Reverses Dopamine Depletion–Induced Dendritic Spine Loss

Striatal medium spiny neurons (MSNs) receive glutamatergic afferents from the cerebral cortex and dopaminergic inputs from the substantia nigra (SN). Striatal dopamine loss decreases the number of MSN dendritic spines. This loss of spines has been suggested to reflect the removal of tonic dopamine i...

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Bibliografiske detaljer
Main Authors: Garcia, Bonnie G., Neely, M. Diana, Deutch, Ariel Y.
Format: Artigo
Sprog:Inglês
Udgivet: Oxford University Press 2010
Fag:
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936803/
https://ncbi.nlm.nih.gov/pubmed/20118184
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/cercor/bhp317
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