Determination of Cancer Risk Associated with Germ Line BRCA1 Missense Variants by Functional Analysis

Germ line inactivating mutations in BRCA1 confer susceptibility for breast and ovarian cancer. However, the relevance of the many missense changes in the gene for which the effect on protein function is unknown remains unclear. Determination of which variants are causally associated with cancer is i...

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書誌詳細
主要な著者: Carvalho, Marcelo A., Marsillac, Sylvia M., Karchin, Rachel, Manoukian, Siranoush, Grist, Scott, Swaby, Ramona F., Urmenyi, Turan P., Rondinelli, Edson, Silva, Rosane, Gayol, Luis, Baumbach, Lisa, Sutphen, Rebecca, Pickard-Brzosowicz, Jennifer L., Nathanson, Katherine L., Sali, Andrej, Goldgar, David, Couch, Fergus J., Radice, Paolo, Monteiro, Alvaro N.A.
フォーマット: Artigo
言語:Inglês
出版事項: 2007
主題:
Article
オンライン･アクセス:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936786/
https://ncbi.nlm.nih.gov/pubmed/17308087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-3297
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