Determination of Cancer Risk Associated with Germ Line BRCA1 Missense Variants by Functional Analysis

Germ line inactivating mutations in BRCA1 confer susceptibility for breast and ovarian cancer. However, the relevance of the many missense changes in the gene for which the effect on protein function is unknown remains unclear. Determination of which variants are causally associated with cancer is i...

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Detalhes bibliográficos
Main Authors: Carvalho, Marcelo A., Marsillac, Sylvia M., Karchin, Rachel, Manoukian, Siranoush, Grist, Scott, Swaby, Ramona F., Urmenyi, Turan P., Rondinelli, Edson, Silva, Rosane, Gayol, Luis, Baumbach, Lisa, Sutphen, Rebecca, Pickard-Brzosowicz, Jennifer L., Nathanson, Katherine L., Sali, Andrej, Goldgar, David, Couch, Fergus J., Radice, Paolo, Monteiro, Alvaro N.A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2007
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936786/
https://ncbi.nlm.nih.gov/pubmed/17308087
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-06-3297
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