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Variable toxicological response to the loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and anoxia in diverse neural immortal cell lines

Immortal cell lines are used to investigate various aspects of neurodegeneration. These cells display high glycolytic turnover rate and produce an abundant amounts of lactate. Our previous studies indicate that these cells survive the loss of mitochondrial oxidative phosphorylation (OXPHOS) with amp...

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Detalhes bibliográficos
Main Authors: Mazzio, Elizabeth A., Soliman, Youssef I., Soliman, Karam F. A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936656/
https://ncbi.nlm.nih.gov/pubmed/20401737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-010-9161-7
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