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Variable toxicological response to the loss of OXPHOS through 1-methyl-4-phenylpyridinium-induced mitochondrial damage and anoxia in diverse neural immortal cell lines

Immortal cell lines are used to investigate various aspects of neurodegeneration. These cells display high glycolytic turnover rate and produce an abundant amounts of lactate. Our previous studies indicate that these cells survive the loss of mitochondrial oxidative phosphorylation (OXPHOS) with amp...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Mazzio, Elizabeth A., Soliman, Youssef I., Soliman, Karam F. A.
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936656/
https://ncbi.nlm.nih.gov/pubmed/20401737
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s10565-010-9161-7
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