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Structure-based modeling of the functional HIV-1 intasome and its inhibition
The intasome is the basic recombination unit of retroviral integration, comprising the integrase protein and the ends of the viral DNA made by reverse transcription. Clinical inhibitors preferentially target the DNA-bound form of integrase as compared with the free protein, highlighting the critical...
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| Main Authors: | , , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
National Academy of Sciences
2010
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2936642/ https://ncbi.nlm.nih.gov/pubmed/20733078 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1002346107 |
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