Nucleo-Cytoplasmic Localization Domains Regulate Krüppel-Like Factor 6 (KLF6) Protein Stability and Tumor Suppressor Function

BACKGROUND: The tumor suppressor KLF6 and its oncogenic cytoplasmic splice variant KLF6-SV1 represent a paradigm in cancer biology in that their antagonistic cancer functions are encoded within the same gene. As a consequence of splicing, KLF6-SV1 loses both the C-terminus C(2)H(2) three zinc finger...

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Hlavní autoři: Rodríguez, Estefanía, Aburjania, Nana, Priedigkeit, Nolan M., DiFeo, Analisa, Martignetti, John A.
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2010
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936564/
https://ncbi.nlm.nih.gov/pubmed/20844588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0012639
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