Regulatory T cell frequency in patients with melanoma with different disease stage and course, and modulating effects of high-dose interferon-α 2b treatment

BACKGROUND: High-dose interferon-alpha 2b (IFN-α 2b) is the only approved systemic therapy in the United States for the adjuvant treatment of melanoma. The study objective was to explore the immunomodulatory mechanism of action for IFN-α 2b by measuring serum regulatory T cell (Treg), serum transfor...

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Hauptverfasser: Ascierto, Paolo A, Napolitano, Maria, Celentano, Egidio, Simeone, Ester, Gentilcore, Giusy, Daponte, Antonio, Capone, Mariaelena, Caracò, Corrado, Calemma, Rosa, Beneduce, Gerardo, Cerrone, Margherita, De Rosa, Vincenzo, Palmieri, Giuseppe, Castello, Giuseppe, Kirkwood, John M, Marincola, Francesco M, Mozzillo, Nicola
Format: Artigo
Sprache:Inglês
Veröffentlicht: BioMed Central 2010
Schlagworte:
Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2936304/
https://ncbi.nlm.nih.gov/pubmed/20712892
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1479-5876-8-76
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