Effective Drug Delivery, in vitro and in vivo, By Carbon-Based Nanovectors Non-Covalently Loaded With Unmodified Paclitaxel

Many new drugs have low aqueous solubility and high therapeutic efficacy. Paclitaxel (PTX) is a classic example of this type of compound. Here we show that extremely small (<40 nm) hydrophilic carbon clusters (HCCs) that are PEGylated (PEG-HCCs) are effective drug delivery vehicles when simply mi...

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Main Authors: Berlin, Jacob M., Leonard, Ashley D., Pham, Tam T., Sano, Daisuke, Marcano, Daniela C., Yan, Shayou, Fiorentino, Stefania, Milas, Zvonimir L., Kosynkin, Dmitry V., Katherine Price, B., Lucente-Schultz, Rebecca M., Wen, XiaoXia, Gabriela Raso, M., Craig, Suzanne L., Tran, Hai T., Myers, Jeffrey N., Tour, James M.
Format: Artigo
Sprog:Inglês
Udgivet: 2010
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935702/
https://ncbi.nlm.nih.gov/pubmed/20681596
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/nn100975c
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