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Highly efficient elimination of Philadelphia leukemic cells by exposure to bcr/abl antisense oligodeoxynucleotides combined with mafosfamide.

Synthetic oligodeoxynucleotides complementary to the break-point junction of bcr-abl transcripts selectively inhibit the proliferation of Philadelphia-positive leukemic cells, but residual leukemic cells persist in antisense oligodeoxynucleotides-treated cultures. Cyclophosphamide derivatives such a...

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Sparad:
I publikationen:J Clin Invest
Huvudupphov: Skorski, T, Nieborowska-Skorska, M, Barletta, C, Malaguarnera, L, Szcyzlik, C, Chen, S T, Lange, B, Calabretta, B
Materialtyp: Artigo
Språk:Inglês
Utgiven: American Society for Clinical Investigation 1993
Ämnen:
Research Article
Länkar:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC293565/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/8325984/
https://ncbi.nlm.nih.govhttps://doi.org/10.1172/JCI116549
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