Blockade of GITR–GITRL interaction maintains Treg function to prolong allograft survival

Involvement of Treg in transplant tolerance has been demonstrated in multiple models. During the active process of graft rejection, these regulatory cells are themselves regulated and inactivated, a process termed counter-regulation. We hypothesize that ligation of the costimulatory molecule glucoco...

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Autori principali: Kim, James I., Sonawane, Samsher B., Lee, Major K., Lee, Seoung-Hoon, Duff, Patrick E., Moore, Daniel J., O’Connor, Matthew R., Lian, Moh-Moh, Deng, Shaoping, Choi, Yongwon, Yeh, Heidi, Caton, Andrew J., Markmann, James F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2010
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935584/
https://ncbi.nlm.nih.gov/pubmed/20148423
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/eji.200940046
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