GITR blockade facilitates T-reg mediated allograft survival

BACKGROUND: Many models of transplant tolerance have been found to depend upon the induction of regulatory T cells (T-regs). Innate immune signals are known to down-regulate T-regs thereby augmenting immunity by abrogating regulatory T cell function. Such signals may also provide a barrier to transp...

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Autori principali: Sonawane, Samsher B., Kim, James I., Lee, Major K., Lee, Seoung-Hoon, Duff, Patrick E., Moore, Daniel J., Lian, Moh-Moh, Deng, Shaoping, Choi, Yongwon, Yeh, Heidi, Caton, Andrew J., Markmann, James F.
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2009
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC2803064/
https://ncbi.nlm.nih.gov/pubmed/19935370
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1097/TP.0b013e3181ba6f85
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