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Improving disease gene prioritization using the semantic similarity of Gene Ontology terms

Motivation: Many hereditary human diseases are polygenic, resulting from sequence alterations in multiple genes. Genomic linkage and association studies are commonly performed for identifying disease-related genes. Such studies often yield lists of up to several hundred candidate genes, which have t...

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Hlavní autoři: Schlicker, Andreas, Lengauer, Thomas, Albrecht, Mario
Médium: Artigo
Jazyk:Inglês
Vydáno: Oxford University Press 2010
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935448/
https://ncbi.nlm.nih.gov/pubmed/20823322
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/bioinformatics/btq384
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