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Crystallization and preliminary X-ray analysis of mycophenolic acid-resistant and mycophenolic acid-sensitive forms of IMP dehydrogenase from the human fungal pathogen Cryptococcus

Fungal human pathogens such as Cryptococcus neoformans are becoming an increasingly prevalent cause of human morbidity and mortality owing to the increasing numbers of susceptible individuals. The few antimycotics available to combat these pathogens usually target fungal-specific cell-wall or membra...

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Detalhes bibliográficos
Main Authors: Morrow, Carl A., Stamp, Anna, Valkov, Eugene, Kobe, Bostjan, Fraser, James A.
Formato: Artigo
Idioma:Inglês
Publicado em: International Union of Crystallography 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935239/
https://ncbi.nlm.nih.gov/pubmed/20823538
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1107/S1744309110031659
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