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Two mutations in the hormone binding domain of the vitamin D receptor cause tissue resistance to 1,25 dihydroxyvitamin D3.

We have identified and characterized two mutations in the hormone binding domain of the vitamin D receptor (VDR) in patients with hereditary vitamin D-resistant rickets. One patient was found to have a premature stop mutation (CAG to TAG) in the hinge region affecting amino acid 149 (Q149X) and the...

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Xehetasun bibliografikoak
Egile Nagusiak: Kristjansson, K, Rut, A R, Hewison, M, O'Riordan, J L, Hughes, M R
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: 1993
Gaiak:
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC293517/
https://ncbi.nlm.nih.gov/pubmed/8392085
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