Inhibiting Protease-Activated Receptor 4 Limits Myocardial Ischemia/Reperfusion Injury in Rat Hearts by Unmasking Adenosine Signaling

Harnessing endogenous cardioprotectants is a novel therapeutic strategy to combat ischemia/reperfusion (I/R) injury. Thrombin causes I/R injury, whereas exogenous adenosine prevents I/R injury. We hypothesized that blocking thrombin receptor activation with a protease-activated receptor (PAR) 4 anta...

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Hlavní autoři: Strande, Jennifer L., Hsu, Anna, Su, Jidong, Fu, Xiangping, Gross, Garrett J., Baker, John E.
Médium: Artigo
Jazyk:Inglês
Vydáno: 2007
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On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2935083/
https://ncbi.nlm.nih.gov/pubmed/18055876
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/jpet.107.133595
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