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Easy Strategy To Protect Antimicrobial Peptides from Fast Degradation in Serum

Antimicrobial peptides are promising novel peptide leads, but their low serum stability often limits their further consideration in drug development programs. Here, we describe a generally applicable strategy to stabilize peptides against serum proteases by replacing arginine residues with α-amino-3...

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Detalhes bibliográficos
Main Authors: Knappe, Daniel, Henklein, Petra, Hoffmann, Ralf, Hilpert, Kai
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2010
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934954/
https://ncbi.nlm.nih.gov/pubmed/20585128
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00300-10
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