Variable efficacy of thrombospondin 1 against liver and lung metastases due to differential activity of ADAMTS1

Metastases to any organ site require angiogenesis for tumor expansion. Tumor angiogenesis is restrained by a variety of endogenous inhibitors including thrombospondin 1 (TSP1). The principal anti-angiogenic activity of TSP1 resides in a domain containing 3 TSP1 repeats (3TSR), and TSP1 cleavage is r...

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Detalhes bibliográficos
Main Authors: Lee, Yoon-Jin, Koch, Moritz, Karl, Daniel, Torres-Collado, Antoni X., Fernando, Namali T., Rothrock, Courtney, Kuruppu, Darshini, Ryeom, Sandra, Iruela-Arispe, M. Luisa, Yoon, Sam S.
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934910/
https://ncbi.nlm.nih.gov/pubmed/20103648
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/0008-5472.CAN-09-3094
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