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Semaphorin 4D/Plexin-B1 Stimulates PTEN Activity through R-Ras GTPase-activating Protein Activity, Inducing Growth Cone Collapse in Hippocampal Neurons

Plexins are receptors for axonal guidance molecules semaphorins. We recently reported that the semaphorin 4D (Sema4D) receptor, Plexin-B1, suppresses PI3K signaling through the R-Ras GTPase-activating protein (GAP) activity, inducing growth cone collapse. Phosphatidylinositol 3-phosphate level is cr...

Ausführliche Beschreibung

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Bibliographische Detailangaben
Hauptverfasser: Oinuma, Izumi, Ito, Yuri, Katoh, Hironori, Negishi, Manabu
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2010
Schlagworte:
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934685/
https://ncbi.nlm.nih.gov/pubmed/20610402
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.147546
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