Neurons Efficiently Repair Glutamate-induced Oxidative DNA Damage by a Process Involving CREB-mediated Up-regulation of Apurinic Endonuclease 1

Glutamate, the major excitatory neurotransmitter in the brain, activates receptors coupled to membrane depolarization and Ca(2+) influx that mediates functional responses of neurons including processes such as learning and memory. Here we show that reversible nuclear oxidative DNA damage occurs in c...

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Autors principals: Yang, Jenq-Lin, Tadokoro, Takashi, Keijzers, Guido, Mattson, Mark P., Bohr, Vilhelm A.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Biochemistry and Molecular Biology 2010
Matèries:
DNA and Chromosomes
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934684/
https://ncbi.nlm.nih.gov/pubmed/20573957
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M109.082883
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