Fkbp52 Regulates Androgen Receptor Transactivation Activity and Male Urethra Morphogenesis

Hypospadias is a common birth defect in humans, yet its etiology and pattern of onset are largely unknown. Recent studies have shown that male mice with targeted ablation of FK506-binding protein-52 (Fkbp52) develop hypospadias, most likely due to actions of Fkbp52 as a molecular co-chaperone of the...

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Hlavní autoři: Chen, Hanying, Yong, Weidong, Hinds, Terry D., Yang, Zuocheng, Zhou, Yuhong, Sanchez, Edwin R., Shou, Weinian
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2010
Témata:
Developmental Biology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934645/
https://ncbi.nlm.nih.gov/pubmed/20605780
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.156091
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