Asparagine of z8 Insert Is Critical for the Affinity, Conformation, and Acetylcholine Receptor-clustering Activity of Neural Agrin

Agrin isoforms with different bioactivities are synthesized by the nerve and the muscle. Neural agrin containing an 8-amino acid insert (z8) introduced by alternative splicing is the active form that induces synaptic differentiation at the neuromuscular junction. In addition to alternative splicing,...

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Bibliographic Details
Main Authors: Tseng, Chao-Neng, Zhang, Lili, Wu, Shey-Lin, Wang, Wen-Fu, Wang, Zuo-Zhong, Cascio, Michael
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2010
Subjects:
Neurobiology
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2934632/
https://ncbi.nlm.nih.gov/pubmed/20566625
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M110.130625
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